The Pelican 1510 LOC is one of the more unusual wheeled carry-on bags I've seen. It's fairly rugged, with a hard-shell exterior that claims to be watertight and crush proof.
The interior features two removable pouches. One is clearly designed for accessories--power cords, cables, and such. The other is for a small-medium-sized laptop. Both pouches affix to the bag's inside lid with Velcro.
Because of its hard shell, those who tend to overpack (meaning: me) would probably feel constrained by this bag. At $232, it's a bit pricey, too. However, I could see using the Pelican 1510 LOC to safely transport a variety of gear, such as laptop, projector, portable printer, camera equipment, and accessories.